Both the Escalade IQ and G-Class have child safety locks to prevent children from opening the rear doors. The Escalade IQ has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The G-Class’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Escalade IQ has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The G-Class doesn’t offer front seat center airbags.
A passive infrared night vision system standard on the Escalade IQ Premium helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The G-Class doesn’t offer a night vision system.
Both the Escalade IQ and the G-Class have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all-wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, around view monitors, rear cross-path warning and driver alert monitors.
The Cadillac Escalade IQ weighs 2083 to 3586 pounds more than the Mercedes G-Class. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

